Gingival overgrowth is a well-documented side effect of cyclosporine administration in both dogs and people [ 3, 4, 5, 6, 7, 8 ]. The exact incidence of occurrence is unknown, but is thought to affect approximately 2%-3% of canine patients treated for atopic dermatitis with the medication [ 3, 9 ] Gingival overgrowth (GO) is a well-documented unwanted effect associated with the systemic use of cyclosporin A (CsA). This molecule is an immunosuppressive drug extensively used for the prevention of organ transplant rejection as well as the management of a number of autoimmune conditions [ plaque/gingivitis and gingival overgrowth. Keywords: Gingival overgrowth, cyclosporine, calcium channel blockers, phenytoin, dental hygiene care, oral hygiene instructions, periodontal maintenance Introduction Patients affected by a variety of medical conditions may require modifications in dental care. One such example is whe . Gingival hyperplasia improved in all patients (P < 0.001, Friedman test). The degree of improvement was better when the degree of hyperplasia was lower
The drug most frequently associated with gingival hyperplasia in veterinary patients is cyclosporine. Cyclosporine is an immunosuppressive drug that is used to manage allergic and autoimmune diseases The degree of gingival hyperplasia is unrelated to the dose and levels of cyclosporine. Usually, the gingival overgrowth regresses after discontinuing the drug, they further added. case report cyclosporine gingival hyperplasia gum disease overgrowth journal of the association of physicians of indi Gingival hyperplasia is a simple overgrowth of gum tissue, principally the fibrous submucosa. The hyperplasia can become severe enough to bury incisor teeth (Fig. 7-40). Gingival hyperplasia is most common in brachycephalic dog breeds and is present in 30% of boxer dogs older than 5 years Gingival hyperplasia caused by cyclosporine in an atopic dog. Amongst the various potential adverse effects of cyclosporine in dogs is a gingival hyperplasia. It's not dramatic in this patient: they can be much worse. The same phenomenon is seen in people. In human medicine it can be managed with azithromycin in capsule or toothpaste formulation
The clinical therapy for cyclosporine A (CsA)-induced gingival hyperplasia (GH) and the pathological changes in hyperplastic gingival tissues were investigated. Nine cases of CsA-induced GH after renal transplantation were subjected to periodontal non-surgical treatment and surgical treatment and were followed up. Gingival index (GI), dental plaque index (PLI) and GH degree (GHD) at different.
BACKGROUND: It has been shown that azithromycin improves cyclosporine-induced gingival hyperplasia (GH), but its efficacy was never compared against an efficient oral hygiene program (OHP). The aim of this study was to analyze the effects of azithromycin plus OHP versus OHP alone in patients with cyclosporine-induced GH Azithromycin may be effective, especially for cyclosporine-induced gingival hyperplasia in patients who have had renal transplantation. 3. In this patient, nifedipine was switched to an antihypertensive medication of a different class, and he was referred to a dental specialist. After a month, the gingival hyperplasia decreased moderately
The effect of verapamil on the prevalence and severity of cyclosporine-induced gingival overgrowth in renal allograft recipients. J Periodontol. 1996 Nov. 67(11):1201-5. . Conde SA, Aarestrup FM, Vieira BJ, Bastos MG. Roxithromycin reduces cyclosporine-induced gingival hyperplasia in renal transplant patients hepatotoxicity, hypertension, gingival hyperplasia, hypertrichosis, neurotoxicity and altered bone metabolism are some of the important side effects to monitor.4 Gingival hyperplasia is a side effect which needs extensive dental attention. It is disfiguring and affects oral function as well. It may also cause delayed or/and ectopic eruption o Gingival hyperplasia is a known complication of cyclosporine therapy with a frequency between 21-25% in renal transplant patients . A study of clinical trials revealed benefits of systemic azithromycin in such conditions [ 41 ] Hooda and Narula [ 13 ] gave azithromycin to their patients with gingival hyperplasia and symptomatic relief was.
Persistent otitis externa, urinary tract infections, anorexia, gingival hyperplasia, lymphadenopathy and lethargy were the next most frequent adverse events observed. Gingival hyperplasia regressed with dose tapering. Owners of four dogs reported seizures while dogs were receiving cyclosporine Gingival overgrowth associated with cyclosporine A (CsA) is a multifactorial disease. Studies have shown a certain degree of association between gingival overgrowth and potential risk factors, such as age, genetic susceptibility, pharmacokinetic variables, plaque‐related inflammation and immunological changes 1-3.The exact mechanism responsible for the CsA‐induced gingival overgrowth still. The differential diagnosis of gingival hyperplasia includes poor oral hygiene, medications like cyclosporine and phenytoin, systemic illnesses like sarcoidosis or Crohn's disease, hematological disorders like AML, and genetic conditions. Patients can experience gingival hyperplasia because of leukemic infiltration into the gums
Gingival hyperplasia appears in 8% to 85% of patients treated with cyclosporine. Most studies show an association between oral hygiene status and the prevalence and severity of this gingival overgrowth Kwun WH, Suh BY, Kwun KB. Effect of azithromycin in the treartment of cyclosporine-induced gingival hyperplasia in renal transplant recipients. Transplant Proc. 2003 Feb. 35(1):311-2. . Nash MM, Zaltzman JS. Efficacy of azithromycin in the treatment of cyclosporine-induced gingival hyperplasia in renal transplant recipients Gingival hyperplasia is a condition that refers to an overgrowth of your gums (also known as your gingiva). Whereas some people have too little gums to cover their teeth, those with this condition have too much gum tissue. This condition's presentation can vary in severity, from one small bump to a growth of the gums, which almost completely.
Effect of azithromycin in the treartment of cyclosporine-induced gingival hyperplasia in renal transplant recipients. Transplant Proc. 2003 Feb. 35(1):311-2. . Nash MM, Zaltzman JS. Efficacy of azithromycin in the treatment of cyclosporine-induced gingival hyperplasia in renal transplant recipients Gingival hyperplasia is a typical adverse reaction of certain drugs (phenytoin, calcium antagonists and cyclosporine). Drug induced gingival hyperplasia is reversible when the therapy is stopped or modified. If a change of medication is not possible oral hygiene and prophylaxis is critical
[Cyclosporine-induced gingival hyperplasia: report of one case]. Rev Med Chil. 2007; 135(3):370-4 (ISSN: 0034-9887) Bahamondes C; Godoy J. Gingival enlargement can be an adverse effect of cyclosporine A and nifedipine use. It has a high relapse rate if the drugs are not discontinued. There is a genetic predisposition to the development of this. Cyclosporine (Atopica) is a potent systemic immunosuppressant that may cause the susceptibility to infection and the development of neoplasia. Gastrointestinal problems and gingival hyperplasia may occur at the initial recommended dose. Cyclosporine should not be administered to dogs less than 6 months of age or less than 4 lbs of body weight Background: Gingival hyperplasia could occur after the administration of cyclosporine A. Up to 90% of the patients submitted to immunosuppressant drugs have been reported to suffer from this side effect. The role of fibroblasts in gingival hyperplasia has been widely discussed by literature, showing contrasting results
• CYCLOSPORINE- Highly vascularised & foci of chronic inflammatory cells. • PHENYTOIN - fibroblast to collagen ratio normal, oxytalan fibers are numerous . 21. ANTICONVULSANTS • First gingival enlargement reported . • Introduced by Merritt and Putnam in 1938. • Drugs used for the treatment of epilepsy Gingival hyperplasia is a common occurrence in transplant recipients who are taking cyclosporine. This condition can be complicated when calcium channel blockers or phenytoin are added to the armamentarium of medications; it can be painful and may interfere with eating, speech, and appearance. Multiple mechanisms exist for gingival overgrowth Gingival hyperplasia (GH) is a benign enlargement of the gingiva characterized by its increase in size and volume. Causes of GH vary and include: - chronic intake of specific drugs. Multiple medications have been linked to medication-induced gingival hyperplasia (MIGH), including nifedipine, cyclosporine (CsA), and phenytoin Understanding Gingival Hyperplasia (Enlarged Gums) in Dogs Just like humans, dogs can get plaque buildup on their teeth and gums. This plaque, or other bacterial growth along the gum line, can cause gingival hyperplasia.Gingival hyperplasia is a medical condition in which a dog's gum tissue becomes enlarged and inflamed
BACKGROUND: Gingival hyperplasia (GH) is a common side effect of cyclosporine . Azithromycin (Zithromax; AZI) is a macrolide antibiotic reported in case studies to reduce cyclosporine-induced gingival hyperplasia (CIGH) in renal transplant recipients (RTR). METHODS: The efficacy of AZI to treat CIGH. Gingival hyperplasia and hypertrophy are histologic terms used often to describe the clinical appearance of gingival enlargement, an increase in the size or thickness of the gingiva. The term hyperplasia refers to an increased number of normal cells in a normal arrangement, and hypertrophy describes an increase in the size of.
Atopica (cyclosporine) is a potent systemic immunosuppressant that may increase the. susceptibility to infection and the development of neoplasia. Human Warnings: Not for human use. Keep this and all drugs out of reach of children. For use only in dogs. Precautions: Gastrointestinal problems and gingival hyperplasia may occur at the initial. THE PRESENT WORK COLLECTED DATA on the ultrastructural features of the attached gingiva in kidney transplant patients who showed gingival hyperplasia following cyclosporin A (Cy A) treatment. Ultrastructural examination was carried out on biopsies of attached gingiva obtained from 8 male patients (30 to 60 years old) undergoing treatment at the. The use of cyclosporine for immunosuppression in renal transplantation allograft recipients is associated with hypertrichosis, gingival hyperplasia, and hypercholesterolemia. Conversion of patients to tacrolimus may lead to an improvement in these effects with minimal risk of rejection or allograft dysfunction cyclosporine (hirsutism, gingival hyperplasia) prednisone (acne, striae, etc) sirolimus (rash, mouth ulcers) Which maintenance drugs for the prevention of transplant rejection causes diarrhea? tacrolimus cyclosporine mycophenolate azathioprine (low incidence) sirolimus (low incidence Gingival enlargement or gingival overgrowth is the increase in the size of gingiva. It is a common clinical condition usually seen in acute and chronic gingival inflammation. The enlargement of the gingival tissue may also occur due to many other reasons, which include drug intake associated, conditioned, neoplastic or false enlargements
Drug-induced gingival hyperplasia may improve with substitution of other drugs that rarely affect the gingiva, such as barbiturates, valproic acid, and tacrolimus [6, 24-29]. Use of antibiotics such as metronidazole and azithromycin for cyclosporine-induced gingival hyperplasia has been reported [30-32] Perio index flaws are that the gingival recession was not taken into account. - Gingival index: each of the 4 gingival areas of the tooth is given a score from 0 (normal) to 3 (severe inflamed), mostly based on color. Score is totaled per tooth or added all together/ (total teeth #) to give GI person score
Gingival hyperplasia or gingival overgrowth is a common occurrence in patients taking phenytoin, cyclosporine, or calcium channel blockers. Speech, mastication, tooth eruption, and aesthetics may be altered. Controlling the inflammatory component through an appropriate oral hygiene program may benefit the patient by limiting the severity of the gingival overgrowth Gingival hyperplasia is one of the collateral effect of cyclosporine, the exact pathogenesis of cyclosporine induced gingival hyperplasia is uncertain, and it may interfere with normal oral functions causing unpleasant appearance, carry psychological impacts and leads to difficulty in maintaining good oral hygiene Drug-induced gingival overgrowth is a condition caused by side effects of treatment with one of three types of drugs: phenytoin (used in epilepsy treatment), cyclosporine A (used in transplantology after allogenic organ transplants) and calcium channel blockers (used in the treatment of hypertension). Gingival overgrowth leads to inflammation within the gums and periodontium and can amplify. A case of cyclosporine‐induced gingival overgrowth is presented. Overgrown and inflamed gingivae were noted at several sites in the mouth of a patient taking Cyclosporine following a renal transplant. These were associated with areas adjacent to heavy plaque and calculus deposits on the teeth
dence of drug-induced gingival overgrowth and the age of man or animal. In the human, it is reported that the incidence of CsA-induced gingival overgrowth has variably been in the range of 25 to 81%.6,10 On the other hand, the average incidence of PHT-induced gingival overgrowth is about 50% in patients taking thi Background: Drug-induced gingival hyperplasia (DIGH) causes problems with chewing, aesthetics, and pronunciation, and leads to the deterioration of the patient's quality of life (QOL). Thus, the aim of this study was to evaluate the incidence of DIGH using spontaneous reporting system (SRS) databases By inhibiting calcineurin, cyclosporine leads to a fall in IL-2 levels, which impairs T cell growth and activation. This results in an overall suppression of the immune response. However, cyclosporine does come with many adverse effects, of which the most important to remember are nephrotoxicity, gout or hyperuricemia, gingival hyperplasia, and. Management of cyclosporine-induced gingival hyperplasia by use of an argon laser Blankenau, Richard J.; Triolo, P.; Powell, G. L. Abstract. This is a report of a case study with interesting laser applications. A 7 year old female was referred to us for treatment of hyperplastic tissue..
Drug-induced gingival hyperplasia (DIGH) causes problems with chewing, aesthetics, and pronunciation, and leads to the deterioration of the patient's quality of life (QOL). Thus, the aim of this study was to evaluate the incidence of DIGH using spontaneous reporting system (SRS) databases. We analyzed reports of DIGH from SRS databases and calculated the reporting odds ratios (RORs) of. Gingival overgrowth (GO) and gingival enlargement (GE) are terms used to indicate a pathologic increased volume of the gingiva instead of hyperplasia and hypertrophy , previously adopted.Currently there are more than 20 pharmacological formulation that could be considered associated with GO [2-4].These drugs can be divided into 3 categories: Calcium-channel blockers [5-8. Frequent gingival hyperplasia when nifedipine is given concurrently with cyclosporine have been reported. In controlled trials of cyclosporine in psoriasis patients, cyclosporine blood concentrations did not correlate well with either improvement or with side effects such as renal dysfunction T he present work collected data on the ultrastructural features of the attached gingiva in kidney transplant patients who showed gingival hyperplasia following cyclosporin A (Cy A) treatment. Ultrastructural examination was carried out on biopsies of attached gingiva obtained from 8 male patients (30 to 60 years old) undergoing treatment at the Dental Clinic of the University of Ferrara BACKGROUND Gingival overgrowth is one of the major adverse effects of the immunosuppressive drug cyclosporine A (CsA). Although several studies have attempted to determine the immunological mechanisms of gingival hyperplasia (GO) due to CsA therapy, the pathogenesis remains unclear. In this study, the distribution of the peripheral blood leukocytes in a group of renal transplant patients.
Keywords: Gingival hyperplasia, side effect of, phenytoin, nifedipine, cyclosporine. INTRODUCTION Gingival hyperplasia may occur as a result of inflamma- tion, fibrosis or a combination of both(1). Generalised inflam- matory enlargement may occur due to a number of local and systemic conditions. However, fibrous enlargement is main Drug-Induced Gingival Hyperplasia Last Updated: December 15, 2006 Email to a Colleague Synonyms and related keywords: gingival overgrowth, gingival enlargement, gum overgrowth, gum enlargement, gum hyperplasia, cyclosporine, phenytoin, calcium antagonist-induced gingival hyperplasia AUTHOR INFORMATION Section 1 of 1 Sandimmune (cyclosporine) is used with adrenal corticosteroids to prevent organ rejection after a kidney, liver, or heart transplant surgery. Sandimmune is also used to treat people with severe rheumatoid arthritis or severe psoriasis. Side effects of Sandimmune include renal dysfunction, tremor, hirsutism, hypertension, and gum hyperplasia
BACKGROUND: The use of cyclosporine A (CsA) induces hyperplasia of the gingival epithelium in a site-specific response manner, but the molecular mechanism via which the lesion occurs is unclear. The present research aims to investigate the site-specific effect of CsA on the apoptosis of gingival epithelium associated with gingival hyperplasia 07/01/1990 - Young and female patients were at a significantly greater risk of developing cyclosporine-induced gingival hyperplasia than the other patients.07/01/2000 - A previous study suggested that mast cells (MC) are involved in the development of cyclosporin A-induced gingival hyperplasia, since an increased number of MC were observed in the tissue sections of enlarged gingiva Gingival hyperplasia can occur during use of drugs such as diphenylhydantoin, cyclosporine and nifedipine. We report, three cases of gingival hyperplasia induced by amlodipine, a second generation calcium channel blocker. Exact cause of induction of thehyperplasia is not known. Individual variation in metabolism of the drug may be a factor
Gingival enlargement occurs by taking 30-100mg Nefedipine per day . Idiopathic gingival enlargement. It is also termed as gingivostomatitis, elephantiasis, idiopathic fibromatosis, hereditary gingival hyperplasia and congenitally familial fibromatosis. It is a proliferative fibrous lesion that causes aesthetic and functional problems Two of the medications listed were correct answers as they both can cause drug-related gingival hyperplasia: cyclosporine and nifedipine (Procardia). Cyclosporine (an immunosuppressant drug) and nifedipine (a calcium-channel blocker) both can cause this gingival enlargement. Without inflammation, this gingiva will be normal in color and will. Gingival Hyperplasia 2.3% Lymphadenopathy 2.3% The following clinical signs were reported in less than 2% of dogs treated with cyclosporine in the field study: constipation, flatulence, Clostridial organisms in the feces, nausea, regurgitation, polyuria/polydipsia Background and aims. Gingival hyperplasia, a relatively common side effect of antiepileptic and anticonvulsant drugs, occurs in 30‒50% of patients taking phenytoin and 25‒81% of those taking cyclosporine. Gingival hyperplasia due to lack of balance between extracellular synthesis and degradation is associated with increased production of IL-1B, IL-6 and IL-8 by gingival fibroblasts
Hyperplasia of gingival tissues without inflammation may occur in response to various drugs. Hyperplasia is characterized by diffuse, relatively avascular smooth or nodular enlargement of the gingiva, which may almost cover some teeth. The hypertrophied tissue can often be excised. If possible, substitutions are made for the offending drugs recipients. In addition, tacrolimus did not have the adverse effects of hypertrichosis and gingival hyperplasia, and was associated with lower graft failure rates in kidney transplant patients when compared to cyclosporine.2,3 However, both cyclosporine and tacrolimus are limited by their nephrotoxicity Gingival hyperplasia is an overgrowth of gum tissue around the teeth (also known as the gingiva). There are a number of causes of gingival hyperplasia, but the most common is poor oral hygiene. It's the most common cause, and by far the easiest to correct. The second most common cause of gingival hyperplasia is as a side effect of certain.
Nifedipine-induced gingival hyperplasia 4. Despite the relatively high prevalence of nifedipine-induced gingival hyperplasia (3), amlodipine has rarely been reported as the potential etiologic cause of gingival hyperplasia (3,5,6). (Although the incidence of nifedipine-induced gingival hyperplasia is about 10% (3), very few reports of amlodipine-related gingival hyperplasia does exist in the. Gingival hyperplasia is a typical adverse reaction of certain drugs (phenytoin, calcium antagonists and cyclosporine). Drug induced gingival hyperplasia is reversible when the therapy is stopped or modified. If a change of medication is not possible oral hygiene and prophylaxis is critical Drug-Induced Gingival Hyperplasia. Many terms have been used to describe gingival overgrowth (GO). The expression gingival hyperplasia (abnormal increase in the number of normal cells in a normal arrangement in an organ or tissue, which increase in volume) and gingival hypertrophy (enlargement or overgrowth of an organ or part due to.
Gingival hyperplasia, also known as gum overgrowth, is an oral disease that affects dogs, humans, and, to a lesser extent, cats. It manifests as overabundant gingival tissue, or enlarged gums, that creates pseudo-pockets between the gingiva and tooth surface. If left untreated, it often leads to periodontal disease and oral discomfort Histologic analysis of the gingiva revealed mild to moderate gingival epithelial hyperplasia, hyperkeratosis, and mild inflammation. Gingival overgrowth is a known side effect of cyclosporine administration in other species but, to our knowledge, this report is the first description of the condition in rabbits Gingival hypertrophy also known as gingival hyperplasia, gum hypertrophy or gingival enlargement, refers to excessive growth of the gums or gingiva around the necks of the teeth. The hypertrophic gingival tissue may be inflamed (gingivitis), in which case the gums are red, soft, shiny and bleed easily